Research
- Overview
- The Deng Lab focuses on both the fundamental understanding of cellular processes in tissue development and engineering effective biomaterial systems for therapeutic applications.
Our research is based on the convergence of materials science, micro/nano-scale engineering, and cell biology/medicine. Our research program spans from basic science to translational technology. Specifically, our laboratory actively involves three thrust research areas: (1) cell engineering – understanding of cellular processes and research effective methods to modulate cell function (e.g., via delivery of inducerons); (2) advanced biomaterials – rational design of new polymers and composites by exploiting synthetic chemistry and study of cell-material interactions, and (3) regenerative engineering – development of effective bioengineered systems for regeneration of complex tissues and tissue interfaces. There are natural synergies among all the three research areas.
- Cell Engineering
Directing cell fate plays a critical role in tissue regeneration and cell therapy. Developmental and cell biology provides significant insights into cellular processes during the formation, maintenance, degeneration, and regeneration of tissues and organs. For example, simple ions or signaling agents have recently emerged as potential inducers that direct stem cells into prescribed lineages. The focus of our research in this area is to elucidate the role of simple signaling agents in cellular processes and modulate cell functions through engineered delivery technologies.
- Advanced Biomaterials
Functional performance of medical implants necessitates the design of biomaterials with appropriate physical, chemical, and biological properties. Advances in polymer science have allowed for the design of biomaterials for a specific medical application. The major aim of this topic is to develop advanced biomaterials through further understanding of structure-function relationship and material cues on cellular responses. The insights gained from these studies will be used for rational design of new degradable polymers and composites and creation of next generation medical systems/devices.
- Regenerative Engineering
Regenerative engineering focuses on regeneration of tissues by combining tissue engineering with advanced material science, stem cell science, and developmental biology. We are interested in regeneration of various musculoskeletal tissues (e.g., bone, cartilage, tendon, muscle, and the interfaces between tissues) through the development of biomimetic systems that recapitulate the properties of native tissues. Findings from our studies will foster translation of bioengineering for clinical applications.
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